Crambescidin-816 Acts as a Fungicidal with More Potency than Crambescidin-800 and-830, Inducing Cell Cycle Arrest, Increased Cell Size and Apoptosis in Saccharomyces cerevisiae
| Type | : | ACL |
|---|---|---|
| Nature | : | Production scientifique |
| Au bénéfice du Laboratoire | : | Non |
| Statut de publication | : | Publié |
| Année de publication | : | 2013 |
| Auteurs (7) | : | RUBIOLO J,a TERNON Eva LÓPEZ-ALONSO H THOMAS Olivier,p VEGA F,v VIEYTES M,r BOTANA L,m |
| Revue scientifique | : | Marine Drugs |
| Volume | : | 11 |
| Fascicule | : | 11 |
| Pages | : | 4419-4434 |
| DOI | : | 10.3390/md11114419 |
| URL | : | https://www.mdpi.com/1660-3397/11/11/4419 |
| Abstract | : | In this paper, we show the effect of crambescidin-816, -800, and -830 on Saccharomyces cerevisiae viability. We determined that, of the three molecules tested, crambescidin-816 was the most potent. Based on this result, we continued by determining the effect of crambescidin-816 on the cell cycle of this yeast. The compound induced cell cycle arrest in G2/M followed by an increase in cell DNA content and size. When the type of cell death was analyzed, we observed that crambescidin-816 induced apoptosis. The antifungal effect indicates that crambescidins, and mostly crambescidin-816, could serve as a lead compound to fight fungal infections. |
| Mots-clés | : | crambescidine-816; antifungal; cell cycle arrest; apoptosis |
| Commentaire | : | - |
| Tags | : | - |
| Fichier attaché | : | - |
| Citation | : |
Rubiolo JA, Ternon E, López-Alonso H, Thomas OP, Vega FV, Vieytes MR, Botana LM (2013) Crambescidin-816 Acts as a Fungicidal with More Potency than Crambescidin-800 and-830, Inducing Cell Cycle Arrest, Increased Cell Size and Apoptosis in Saccharomyces cerevisiae. Mar Drugs 11: 4419-4434 | doi: 10.3390/md11114419
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