Dynamical Metabolic Model for Optimizing Biotin-Regulated Lipid Production in Microalgae-Bacteria Symbiosis
| Type | : | ACTI |
|---|---|---|
| Nature | : | Production scientifique |
| Au bénéfice du Laboratoire | : | Oui |
| Statut de publication | : | Publié |
| Année de publication | : | 2024 |
| Lieu de publication | : | - |
| Titre de la conférence | : | 12th IFAC Symposium on Advanced Control of Chemical Processes ADCHEM 2024 |
| Lieu de la conférence | : | Toronto, Canada |
| Année de la conférence | : | 2024 |
| Date de début | : | 14/07/2024 |
| Date de fin | : | 12/01/2025 |
| Titre du proceeding | : | 12th IFAC Symposium on Advanced Control of Chemical Processes ADCHEM 2024 |
| Editeur de presse | : | - |
| Volume | : | - |
| Fascicule | : | - |
| Pages | : | |
| Auteurs (2) | : | PESSI Bruno assis BERNARD Olivier |
| Editeurs scientifiques (3) | : | MÖNNIGMANN Martin MESBAH Ali SWARTZ Christopher |
| DOI | : | 10.1016/j.ifacol.2024.08.329 |
| URL | : | https://www.sciencedirect.com/science/article/pii/S2405896324010796 |
| Abstract | : | Exploiting natural symbioses to enhance productivity of bioprocesses is an emerging trend. For optimizing such complex associations of microorganisms, a model of symbiotic interactions is vital. This challenging task has attracted much attention. Here, a reduced metabolic model describing a symbiotic interaction between bacteria E. coli, overproducing vitamin biotin (B7), and microalgae Chlorella is developed. The symbiosis involves B7 exchange, impacting lipid synthesis regulation in microalgae. Our model shows a trade-of between light availability and biotin production, leading to an optimization problem for lipid production. We numerically determine the optimal conditions, demonstrating the feasibility of this strategy to enhance microalgae cultivation. |
| Mots-clés | : | Bioprocess control; Metabolic engineering; Microalgae; Microbial technology; Model reduction; Optimization |
| Commentaire | : | - |
| Tags | : | - |
| Fichier attaché | : | - |
| Citation | : |
Pessi B, Bernard O (2024) Dynamical Metabolic Model for Optimizing Biotin-Regulated Lipid Production in Microalgae-Bacteria Symbiosis. In: Mönnigmann M, Mesbah A, Swartz C (eds) 12th IFAC Symposium on Advanced Control of Chemical Processes ADCHEM 2024. | doi: 10.1016/j.ifacol.2024.08.329
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